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Biopharma & Life Sciences

Upstream Bio Executive Compensation (FY25)

UPB · Executive and director compensation, fiscal 2024 to 2025
Data as of September 7, 2026Latest filing (DEF 14A): April 16, 2026
73 figures on this page, cited to the filing that reported them. See the citations
The fiscal 2025 disclosure covers 3 named executive officers, and disclosures span fiscal 2024 through fiscal 2025. E. Rand Sutherland, Chief Executive Officer, received $4,302,100 in total compensation for fiscal 2025, while compared with the $9,108,953 reported for fiscal 2024, Sutherland's total was 52.8% lower. As an emerging growth company, the company is exempt from the advisory say-on-pay vote.
Chief executive, fiscal 2025
E. Rand Sutherland
This company is not required to report a chief executive pay ratio.
What changed from fiscal 2024 to fiscal 2025
The figures that moved, and by how much. Analysis of these figures is part of the Velarion platform.
Chief executive total compensation — E. Rand Sutherland: $9,108,953$4,302,100 (52.8% lower)

Frequently asked questions

Answers drawn from the data on this page.
Who is Upstream Bio's chief executive and what were they paid?
E. Rand Sutherland, Chief Executive Officer, received $4,302,100 in total compensation for fiscal 2025. Compared with the $9,108,953 reported for fiscal 2024, Sutherland's total was 52.8% lower.
What was Upstream Bio's say-on-pay result?
As an emerging growth company, the company is exempt from the advisory say-on-pay vote.

Executive compensation

Every element reported for each named executive officer, by fiscal year.
Fiscal 2024
OfficerSalaryBonusStock awardsOption awardsNon-equity incentivePension and deferred earningsAll other compensationTotal
E. Rand Sutherland
Chief Executive Officer
Michael Paul Gray
Chief Financial Officer and Chief Operating Officer
Fiscal 2025
OfficerSalaryBonusStock awardsOption awardsNon-equity incentivePension and deferred earningsAll other compensationTotal
E. Rand Sutherland
Chief Executive Officer
Michael Paul Gray
Chief Financial Officer and Chief Operating Officer
Aaron Deykin
Chief Medical Officer and Head of Research and Development
A dash means the company reported no figure in that column. $0 is shown only where the filing prints a zero. A negative change in pension value is shown but, as the company reports it, not included in the total.

Equity awards granted

Individual awards as disclosed: type, date, unit counts at each level, and grant date value.
Fiscal 2025
OfficerAwardGrant dateThreshold unitsTarget unitsUnits grantedMaximum unitsExercise priceGrant date fair value
E. Rand SutherlandOPTION
Fiscal 2024 are included in the PDF.
A dash means the company reported no figure in that column. $0 is shown only where the filing prints a zero. Threshold, target and maximum apply only to performance awards and are never shown for time-based or option awards.

Outstanding awards

Awards still held at fiscal year end.
As disclosed at fiscal 2025 year end
OfficerAwardUnvested unitsMarket value of unvested unitsExercise priceExpires
Aaron DeykinOption02/05/2035
Option05/01/2034
Option
Option06/03/2032
Option08/09/2033
Option03/02/2033
Option06/03/2032
E. SutherlandOption04/24/2034
Option04/03/2034
Option02/05/2035
Michael GrayOption03/26/2034
Option03/26/2034
Option02/05/2035
A dash means the company reported no figure in that column. $0 is shown only where the filing prints a zero.

Director compensation

What each non-employee director was paid.
Fiscal 2025
DirectorFees earned in cashStock awardsOption awardsNon-equity incentivePension and deferred earningsAll other compensationTotal
Ronald C. Renaud, Jr
Board chair
H. Edward Fleming, Jr
Marcella Kuhlman Ruddy
Erez Chimovits, Daniella Beckman, E. Rand Sutherland and Liam Ratcliffe served on the board in fiscal 2025 and received no compensation for board service. Executive directors are typically paid through their executive roles, shown above.
A dash means the company reported no figure in that column. $0 is shown only where the filing prints a zero.

Director fee schedule

The standing retainers and premiums the board pays, as published.
Board cash retainer
Board equity retainer
Total board retainer
Board chair premium
Audit committee chair
Audit committee member
Compensation committee chair
Compensation committee member
Nominating and governance chair
Nominating and governance member
Equity is delivered as Stock Options.

Disclosed peer group

The companies this board named as its compensation comparison group. The list is disclosure; the comparison is analysis.

Say-on-pay history

Shareholder support for the compensation program, by year.
This company is an emerging growth company and is exempt from the advisory vote on executive compensation. There is no vote to report.
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What this page does not include

Everything above is a fact Upstream Bio disclosed, and it is free. Everything below is our analysis of those facts, and it is not.
Written compensation analysis
A read of the pay program as designed and as paid: incentive structure, goal rigor, the alignment between the committee's stated philosophy and what the numbers show.
Executive Compensation Report — $1,500
Board and governance analysis
Committee composition, independence, director pay positioning, and the governance provisions read together rather than listed.
Board Governance Report — $1,200
Realizable pay
What the awards above are actually worth today against what they were valued at on grant, and what the gap says about the pay-for-performance link.
Velarion Intelligence
Adviser switching and vote outcomes
Two datasets covering compensation-adviser changes and what followed a contested vote. Both are part of the Velarion platform.
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Citations

Every figure on this page is cited to the document that reported it. Select any figure to see its citation.
73 figures on this page, cited to the filing that reported them.
73 cited to the filing

Documents cited

  1. 0001193125-26-158966
    2025 Director Compensation Table · 2025 Summary Compensation Table · EXE CUTIVE COMPENSATION · Non-Employee Director Compensation · and 1 more section
  2. 0000950170-25-055372
    2024 Summary Compensation Table
Cite this data
This page is free to cite. Attribution we ask for:
Velarion, “Upstream Bio executive compensation, FY2024–FY2025.” https://intel.velarion.ai/comp/UPB (accessed 2026).
Short form: data: Velarion
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The headline figures, each with its citation.
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Biopharma & Life Sciences rankings

Chief executive payBiopharma & Life SciencesCEO pay ratioBiopharma & Life SciencesSay-on-pay supportBiopharma & Life Sciences

Terms on this page

Say-on-Pay VoteCEO Pay RatioMedian Employee CompensationAll companies
Cite this data
APA
Velarion Company Intelligence. (2026). Velarion database: executive and board compensation data (Version 2026Q3) [Data set]. Zenodo. https://doi.org/10.5281/zenodo.22283854
BibTeX
@misc{velarionData2026,
  author = {{Velarion Company Intelligence}},
  title = {Velarion database: executive and board compensation data},
  year = {2026},
  version = {2026Q3},
  doi = {10.5281/zenodo.22283854},
  publisher = {Zenodo},
  url = {https://doi.org/10.5281/zenodo.22283854}
}
For informational purposes only. Not investment, legal, or compensation advice.  The Pay Desk · Methodology · Terms · Privacy